功能： catalytic activity:UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.,cofactor:Manganese.,function:Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 43 family.,subunit:Homodimer .,tissue specificity:Mainly expressed in the brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Golgi apparatus membrane ; Single-pass type II membrane protein . Secreted .; [Isoform 2]: Golgi apparatus membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane . Secreted .
功能： catalytic activity:UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.,cofactor:Manganese.,function:Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 43 family.,subunit:Homodimer .,tissue specificity:Mainly expressed in the brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Golgi apparatus membrane ; Single-pass type II membrane protein . Secreted .; [Isoform 2]: Golgi apparatus membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane . Secreted .
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