Caspase-10 B/D Polyclonal Antibody

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商品货号： PLA015060

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： CASP10
蛋白名称： Caspase10
Human_gene_id： 843
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=843
Human_swiss_prot_no： Q92851-2/4
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q92851-2/entry
特异性： Caspase-10 B/D Polyclonal Antibody detects endogenous levels of proCaspase-10 B/D protein, actived Caspase-10 (isoform B and D) and Caspase-10(isoform B and D) subunit p12,
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ALPS2; apoptotic protease Mch-4; CASP-10; CASPA; caspase-10; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-convert
实测条带： pro: 60kD, actived: 33kD 12kD
功能： catalytic activity:Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp-|-Gly.,disease:Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.,disease:Defects in CASP10 are a cause of gastric cancers [MIM:137215].,disease:Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.,function:Isoform C is proteolytically inactive.,online information:CASP10 mutation db,online information:Caspase-10 mutations causing ALPS type II,PTM:Cleavage by granzyme B and autocatalytic activity generate the two active subunits.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 2 DED (death effector) domains.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit (By similarity). Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10.,tissue specificity:Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： cytosol,CD95 death-inducing signaling complex,ripoptosome,
组织表达： Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
tag： hot
科研货号： PLA015060

Caspase-10 B/D Polyclonal Antibody

Catalog No PLA015060

Product information

基因名称： CASP10
蛋白名称： Caspase10
Human_gene_id： 843
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=843
Human_swiss_prot_no： Q92851-2/4
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q92851-2/entry
特异性： Caspase-10 B/D Polyclonal Antibody detects endogenous levels of proCaspase-10 B/D protein, actived Caspase-10 (isoform B and D) and Caspase-10(isoform B and D) subunit p12,
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ALPS2; apoptotic protease Mch-4; CASP-10; CASPA; caspase-10; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-convert
实测条带： pro: 60kD, actived: 33kD 12kD
功能： catalytic activity:Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp-|-Gly.,disease:Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.,disease:Defects in CASP10 are a cause of gastric cancers [MIM:137215].,disease:Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.,function:Isoform C is proteolytically inactive.,online information:CASP10 mutation db,online information:Caspase-10 mutations causing ALPS type II,PTM:Cleavage by granzyme B and autocatalytic activity generate the two active subunits.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 2 DED (death effector) domains.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit (By similarity). Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10.,tissue specificity:Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： cytosol,CD95 death-inducing signaling complex,ripoptosome,
组织表达： Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
tag： hot
科研货号： PLA015060

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