Casein Kinase Iδ Polyclonal Antibody

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商品货号： PLA015058

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： CSNK1D
蛋白名称： Casein kinase I isoform delta
Human_gene_id： 1453
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1453
Human_swiss_prot_no： P48730
Human_swiss_link： http://www.uniprot.org/uniprotkb/P48730/entry
Mouse_gene_id： 104318
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=104318
Mouse_swiss_prot_no： Q9DC28
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9DC28
Rat_gene_id： 64462
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64462
Rat_swiss_prot_no： Q06486
Rat_swiss_link： http://www.uniprot.org/uniprot/Q06486
特异性： Casein Kinase Iδ Polyclonal Antibody detects endogenous levels of Casein Kinase Iδ protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CSNK1D; HCKID; Casein kinase I isoform delta; CKI-delta; CKId; Tau-protein kinase CSNK1D
实测条带： 47kD
信号通路： Hedgehog;Gap junction;Circadian rhythm;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.,enzyme regulation:Exhibits substrate-dependent heparin activation.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.,PTM:Autophosphorylated on serine and threonine residues.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation.,tissue specificity:Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopioetic cells and mature granulocytes. Also found in monocytes and lymphocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.
组织表达： Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
科研货号： PLA015058

Casein Kinase Iδ Polyclonal Antibody

Catalog No PLA015058

Product information

基因名称： CSNK1D
蛋白名称： Casein kinase I isoform delta
Human_gene_id： 1453
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1453
Human_swiss_prot_no： P48730
Human_swiss_link： http://www.uniprot.org/uniprotkb/P48730/entry
Mouse_gene_id： 104318
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=104318
Mouse_swiss_prot_no： Q9DC28
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9DC28
Rat_gene_id： 64462
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64462
Rat_swiss_prot_no： Q06486
Rat_swiss_link： http://www.uniprot.org/uniprot/Q06486
特异性： Casein Kinase Iδ Polyclonal Antibody detects endogenous levels of Casein Kinase Iδ protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CSNK1D; HCKID; Casein kinase I isoform delta; CKI-delta; CKId; Tau-protein kinase CSNK1D
实测条带： 47kD
信号通路： Hedgehog;Gap junction;Circadian rhythm;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.,enzyme regulation:Exhibits substrate-dependent heparin activation.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.,PTM:Autophosphorylated on serine and threonine residues.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation.,tissue specificity:Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopioetic cells and mature granulocytes. Also found in monocytes and lymphocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.
组织表达： Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
科研货号： PLA015058

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