功能： PTM:Arg-361 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain.,sequence caution:Exon duplication.,similarity:Belongs to the ataxin-2 family.,subunit:Interacts with MPL/TPOR and EPOR and dissociates after ligand stimulation.,tissue specificity:Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Peripheral membrane protein . Cytoplasm . Nucleus speckle . Cytoplasmic granule . Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791). .
组织表达： Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.
功能： PTM:Arg-361 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain.,sequence caution:Exon duplication.,similarity:Belongs to the ataxin-2 family.,subunit:Interacts with MPL/TPOR and EPOR and dissociates after ligand stimulation.,tissue specificity:Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Peripheral membrane protein . Cytoplasm . Nucleus speckle . Cytoplasmic granule . Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791). .
组织表达： Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.
在线咨询
湘公网安备