Arkadia Polyclonal Antibody

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商品货号： PLA014773

适应性： 人,小鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： RNF111
蛋白名称： E3 ubiquitin-protein ligase Arkadia
Human_gene_id： 54778
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54778
Human_swiss_prot_no： Q6ZNA4
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q6ZNA4/entry
Mouse_gene_id： 93836
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93836
Mouse_swiss_prot_no： Q99ML9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q99ML9
特异性： Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
实测条带： 110kD
功能： function:Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Upon TGF-beta treatment, translocates from nucleus to cytosol.,subunit:Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7.,tissue specificity:Broadly expressed.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Upon TGF-beta treatment, translocates from nucleus to cytosol. .
组织表达： Broadly expressed.
科研货号： PLA014773

Arkadia Polyclonal Antibody

Catalog No PLA014773

Product information

基因名称： RNF111
蛋白名称： E3 ubiquitin-protein ligase Arkadia
Human_gene_id： 54778
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54778
Human_swiss_prot_no： Q6ZNA4
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q6ZNA4/entry
Mouse_gene_id： 93836
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93836
Mouse_swiss_prot_no： Q99ML9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q99ML9
特异性： Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
实测条带： 110kD
功能： function:Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Upon TGF-beta treatment, translocates from nucleus to cytosol.,subunit:Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7.,tissue specificity:Broadly expressed.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Upon TGF-beta treatment, translocates from nucleus to cytosol. .
组织表达： Broadly expressed.
科研货号： PLA014773

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