其他名称： ARHGAP17; RICH1; MSTP066; MSTP110; Rho GTPase-activating protein 17; Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs protein 1; RICH-1
实测条带： 100kD
功能： domain:The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions.,function:Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1.,similarity:Contains 1 BAR domain.,similarity:Contains 1 Rho-GAP domain.,subcellular location:Associates with membranes and concentrates at sites of cell-cell contact.,subunit:Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with SLC9A3R1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.,tissue specificity:Ubiquitously expressed. Expressed at higher level in heart and placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Associates with membranes and concentrates at sites of cell-cell contact.
组织表达： Ubiquitously expressed. Expressed at higher level in heart and placenta.
其他名称： ARHGAP17; RICH1; MSTP066; MSTP110; Rho GTPase-activating protein 17; Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs protein 1; RICH-1
实测条带： 100kD
功能： domain:The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions.,function:Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1.,similarity:Contains 1 BAR domain.,similarity:Contains 1 Rho-GAP domain.,subcellular location:Associates with membranes and concentrates at sites of cell-cell contact.,subunit:Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with SLC9A3R1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.,tissue specificity:Ubiquitously expressed. Expressed at higher level in heart and placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Associates with membranes and concentrates at sites of cell-cell contact.
组织表达： Ubiquitously expressed. Expressed at higher level in heart and placenta.
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