其他名称： RNF14; ARA54; HRIHFB2038; E3 ubiquitin-protein ligase RNF14; Androgen receptor-associated protein 54; HFB30; RING finger protein 14; Triad2 protein
实测条带： 50kD
功能： caution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.,domain:The RING-type zinc finger is essential for the interaction with UBE2E2.,function:Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.,pathway:Protein modification; protein ubiquitination.,PTM:RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination.,similarity:Belongs to the RBR family. RNF14 subfamily.,similarity:Contains 1 IBR-type zinc finger.,similarity:Contains 1 RWD domain.,similarity:Contains 2 RING-type zinc fingers.,subunit:Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2 and in the presence of testosterone, with the androgen receptor (AR).,tissue specificity:Widely expressed.,
其他名称： RNF14; ARA54; HRIHFB2038; E3 ubiquitin-protein ligase RNF14; Androgen receptor-associated protein 54; HFB30; RING finger protein 14; Triad2 protein
实测条带： 50kD
功能： caution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.,domain:The RING-type zinc finger is essential for the interaction with UBE2E2.,function:Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.,pathway:Protein modification; protein ubiquitination.,PTM:RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination.,similarity:Belongs to the RBR family. RNF14 subfamily.,similarity:Contains 1 IBR-type zinc finger.,similarity:Contains 1 RWD domain.,similarity:Contains 2 RING-type zinc fingers.,subunit:Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2 and in the presence of testosterone, with the androgen receptor (AR).,tissue specificity:Widely expressed.,
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