14-3-3 β/ζ Polyclonal Antibody

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商品货号： PLA014488

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： YWHAB/YWHAZ
蛋白名称： 14-3-3 protein beta/alpha/14-3-3 protein zeta/delta
Human_gene_id： 7534/7529
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7534
Human_swiss_prot_no： P63104/P31946
Human_swiss_link： http://www.uniprot.org/uniprotkb/P63104/entry
Mouse_gene_id： 22631/54401
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22631
Rat_gene_id： 25578/56011
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25578
Rat_swiss_prot_no： P63102/P35213
Rat_swiss_link： http://www.uniprot.org/uniprot/P63102
特异性： 14-3-3 β/ζ Polyclonal Antibody detects endogenous levels of 14-3-3 β/ζ protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： YWHAZ; 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1; YWHAB; 14-3-3 protein beta/alpha; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
实测条带： 24kD
信号通路： Akt_PKB;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;Neurotrophin;Pathogenic Escherichia coli infection;
功能： caution:Was originally (PubMed:1577711) thought to have phospholipase A2 activity.,function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,PTM:The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1.,similarity:Belongs to the 14-3-3 family.,subcellular location:Located to stage I to stage IV melanosomes.,subunit:Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with PCTK1 and BSPRY (By similarity). Interacts with WEE1 (C-terminal) (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with AANAT ('Thr-31' phosphorylated form); the interaction modulates AANAT enzymatic activity through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT ('Ser-205' phosphorylated form), can bind the other YWHAZ monomer with similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Melanosome . Located to stage I to stage IV melanosomes.
组织表达： B-cell lymphoma,Bone marrow
科研货号： PLA014488

14-3-3 β/ζ Polyclonal Antibody

Catalog No PLA014488

Product information

基因名称： YWHAB/YWHAZ
蛋白名称： 14-3-3 protein beta/alpha/14-3-3 protein zeta/delta
Human_gene_id： 7534/7529
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7534
Human_swiss_prot_no： P63104/P31946
Human_swiss_link： http://www.uniprot.org/uniprotkb/P63104/entry
Mouse_gene_id： 22631/54401
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22631
Rat_gene_id： 25578/56011
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25578
Rat_swiss_prot_no： P63102/P35213
Rat_swiss_link： http://www.uniprot.org/uniprot/P63102
特异性： 14-3-3 β/ζ Polyclonal Antibody detects endogenous levels of 14-3-3 β/ζ protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： YWHAZ; 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1; YWHAB; 14-3-3 protein beta/alpha; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
实测条带： 24kD
信号通路： Akt_PKB;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;Neurotrophin;Pathogenic Escherichia coli infection;
功能： caution:Was originally (PubMed:1577711) thought to have phospholipase A2 activity.,function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,PTM:The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1.,similarity:Belongs to the 14-3-3 family.,subcellular location:Located to stage I to stage IV melanosomes.,subunit:Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with PCTK1 and BSPRY (By similarity). Interacts with WEE1 (C-terminal) (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with AANAT ('Thr-31' phosphorylated form); the interaction modulates AANAT enzymatic activity through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT ('Ser-205' phosphorylated form), can bind the other YWHAZ monomer with similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Melanosome . Located to stage I to stage IV melanosomes.
组织表达： B-cell lymphoma,Bone marrow
科研货号： PLA014488

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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