功能： Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, P-body . Mammalian P-bodies are also known as GW bodies (GWBs). .
组织表达： Ubiquitous.
科研货号： PLA014446
GW182 rabbit pAb
Catalog NoPLA014446
Product information
基因名称： TNRC6A CAGH26 KIAA1460 TNRC6
蛋白名称： Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)
功能： Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, P-body . Mammalian P-bodies are also known as GW bodies (GWBs). .
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