功能： Major iron transporter that plays a key role in balancing cellular and systemic iron levels . Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Localized to the basolateral membrane of polarized epithelial cells.
组织表达： Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen.
科研货号： PLA014437
SLC40A1 rabbit pAb
Catalog NoPLA014437
Product information
基因名称： SLC40A1 FPN1 IREG1 SLC11A3 MSTP079
蛋白名称： Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
功能： Major iron transporter that plays a key role in balancing cellular and systemic iron levels . Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Localized to the basolateral membrane of polarized epithelial cells.
组织表达： Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen.
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