功能： Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion .
组织表达： Highly expressed in adult T-cell leukemia cell line.
科研货号： PLA014428
Noxa rabbit pAb
Catalog NoPLA014428
Product information
基因名称： PMAIP1 NOXA
蛋白名称： Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)
功能： Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion .
组织表达： Highly expressed in adult T-cell leukemia cell line.
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