功能： Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival . Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted, extracellular space . Mitochondrion . Endoplasmic reticulum . Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7. .
组织表达： Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.
科研货号： PLA014411
Neudesin/NENF rabbit pAb
Catalog NoPLA014411
Product information
基因名称： NENF CIR2 SPUF
蛋白名称： Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Secreted protein of unknown function) (SPUF protein)
功能： Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival . Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted, extracellular space . Mitochondrion . Endoplasmic reticulum . Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7. .
组织表达： Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.
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