功能： RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation . Shows a preference for uridine-rich RNAs . Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 . Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) . Possesses nucleolytic activity against cytotoxic lymphocyte target cells . May be involved in apoptosis .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Cytolytic granule . Cytoplasm, Stress granule . Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity). Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). .
组织表达： Expressed in brain, heart, kidney, lung and skeletal muscle.
功能： RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation . Shows a preference for uridine-rich RNAs . Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 . Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) . Possesses nucleolytic activity against cytotoxic lymphocyte target cells . May be involved in apoptosis .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Cytolytic granule . Cytoplasm, Stress granule . Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity). Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). .
组织表达： Expressed in brain, heart, kidney, lung and skeletal muscle.
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