蛋白名称： Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1)
功能： Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. ; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm .; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). .; [Isoform 4]: Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus.
组织表达： Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
科研货号： PLA014262
ANKS1B rabbit pAb
Catalog NoPLA014262
Product information
基因名称： ANKS1B
蛋白名称： Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1)
功能： Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. ; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm .; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). .; [Isoform 4]: Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus.
组织表达： Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
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