功能： Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell membrane . Nucleus . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell projection, filopodium . Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate (PubMed:15023524). Binds to actin filaments (PubMed:15023524). .
组织表达： Broadly expressed in the immune system and can be detected in T and B-cells.
科研货号： PLA014246
DEF6 rabbit pAb
Catalog NoPLA014246
Product information
基因名称： DEF6 IBP
蛋白名称： Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein)
功能： Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell membrane . Nucleus . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell projection, filopodium . Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate (PubMed:15023524). Binds to actin filaments (PubMed:15023524). .
组织表达： Broadly expressed in the immune system and can be detected in T and B-cells.
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