功能： Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion matrix. Cytoplasm, cytosol . Cell junction, synapse, postsynaptic cell membrane ; Peripheral membrane protein . Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. .
组织表达： Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
科研货号： PLA014240
TID1 rabbit pAb
Catalog NoPLA014240
Product information
基因名称： DNAJA3 HCA57 TID1
蛋白名称： DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)
功能： Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion matrix. Cytoplasm, cytosol . Cell junction, synapse, postsynaptic cell membrane ; Peripheral membrane protein . Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. .
组织表达： Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
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