功能： [Isoform 1]: E3 ubiquitin-protein ligase . May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 . Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . ; [Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Cytoplasm, cytosol . Mitochondrion . Nucleus . Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. .; [Isoform 2]: Nucleus . Colocalizes with CDKN1A in the nucleus. .
组织表达： Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
科研货号： PLA014038
TRIM39 rabbit pAb
Catalog NoPLA014038
Product information
基因名称： TRIM39 RNF23 TFP
蛋白名称： E3 ubiquitin-protein ligase TRIM39 (EC 6.3.2.-) (RING finger protein 23) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)
功能： [Isoform 1]: E3 ubiquitin-protein ligase . May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 . Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . ; [Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Cytoplasm, cytosol . Mitochondrion . Nucleus . Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. .; [Isoform 2]: Nucleus . Colocalizes with CDKN1A in the nucleus. .
组织表达： Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
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