功能： Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity . Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide . Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer . Plays a key role in skeletal muscle function and regeneration (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Golgi apparatus membrane ; Single-pass type II membrane protein .
组织表达： Ubiquitous. Highest expression in heart, brain and skeletal muscle.
科研货号： PLA013991
LARGE rabbit pAb
Catalog NoPLA013991
Product information
基因名称： LARGE KIAA0609 LARGE1
蛋白名称： Glycosyltransferase-like protein LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A)
功能： Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity . Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide . Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer . Plays a key role in skeletal muscle function and regeneration (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Golgi apparatus membrane ; Single-pass type II membrane protein .
组织表达： Ubiquitous. Highest expression in heart, brain and skeletal muscle.
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