功能： Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell surface . Cytoplasm, cytoskeleton, cilium basal body . Enriched at the apical surface in ciliated cells. .
科研货号： PLA013986
INTU rabbit pAb
Catalog NoPLA013986
Product information
基因名称： INTU KIAA1284 PDZD6 PDZK6
蛋白名称： Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6)
功能： Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell surface . Cytoplasm, cytoskeleton, cilium basal body . Enriched at the apical surface in ciliated cells. .
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