功能： Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation . Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid . In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate . Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Microsome membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .
组织表达： Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain.
功能： Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation . Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid . In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate . Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Microsome membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .
组织表达： Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain.
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