功能： Lipase that primarily hydrolyzes triglycerides and galactosylglycerides . In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides . Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity . Can completely deacylate triacylglycerols . When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids . Hydrolyzes medium- and long-chain fatty acyls in galactolipids . May act together with LIPF to hydrolyze partially digested triglycerides . Hydrolyzes long-chain monoglycerides with high efficiency . In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity . In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted . Zymogen granule membrane ; Peripheral membrane protein . Cell projection, neuron projection . Localizes to neurite tips in neuronal cells. .
功能： Lipase that primarily hydrolyzes triglycerides and galactosylglycerides . In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides . Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity . Can completely deacylate triacylglycerols . When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids . Hydrolyzes medium- and long-chain fatty acyls in galactolipids . May act together with LIPF to hydrolyze partially digested triglycerides . Hydrolyzes long-chain monoglycerides with high efficiency . In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity . In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted . Zymogen granule membrane ; Peripheral membrane protein . Cell projection, neuron projection . Localizes to neurite tips in neuronal cells. .
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