功能： Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes . In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP . May play a role in myelin formation (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Forms discrete, punctate intracellular vesicles. .
组织表达： [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver. ; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.
科研货号： PLA013733
ABCA2 rabbit pAb
Catalog NoPLA013733
Product information
基因名称： ABCA2 ABC2 KIAA1062
蛋白名称： ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2)
功能： Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes . In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP . May play a role in myelin formation (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Forms discrete, punctate intracellular vesicles. .
组织表达： [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver. ; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.
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