功能： Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis . May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion . Mitochondrion outer membrane . Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side . Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. .
组织表达： Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919).
科研货号： PLA013627
FATE1 rabbit pAb
Catalog NoPLA013627
Product information
基因名称： FATE1 FATE
蛋白名称： Fetal and adult testis-expressed transcript protein (Cancer/testis antigen 43) (CT43) (Tumor antigen BJ-HCC-2)
功能： Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis . May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion . Mitochondrion outer membrane . Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side . Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. .
组织表达： Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919).
在线咨询
湘公网安备