功能： Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm . Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain . Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 . Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 . This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm .; [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion .
组织表达： Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.
科研货号： PLA013483
HSCB rabbit pAb
Catalog NoPLA013483
Product information
基因名称： HSCB DNAJC20 HSC20
蛋白名称： Iron-sulfur cluster co-chaperone protein HscB, mitochondrial (DnaJ homolog subfamily C member 20) (Hsc20)
功能： Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm . Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain . Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 . Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 . This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm .; [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion .
组织表达： Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.
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