功能： As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus outer membrane ; Single-pass type IV membrane protein . Localization at the nucleus outer membrane requires the presence of SUN1. .
科研货号： PLA013424
Nesprin 4 rabbit pAb
Catalog NoPLA013424
Product information
基因名称： SYNE4 C19orf46
蛋白名称： Nesprin-4 (Nuclear envelope spectrin repeat protein 4)
功能： As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus outer membrane ; Single-pass type IV membrane protein . Localization at the nucleus outer membrane requires the presence of SUN1. .
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