功能： Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes . ; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).
组织表达： Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.
功能： Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes . ; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).
组织表达： Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.
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