功能： Involved in pre-mRNA splicing as component of the spliceosome . Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis . Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly . May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing . Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus, nucleoplasm . Localizes to speckle-like regions of the nucleoplasm. .
科研货号： PLA013064
AQR rabbit pAb
Catalog NoPLA013064
Product information
基因名称： AQR KIAA0560
蛋白名称： Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160)
功能： Involved in pre-mRNA splicing as component of the spliceosome . Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis . Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly . May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing . Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus, nucleoplasm . Localizes to speckle-like regions of the nucleoplasm. .
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