功能： Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Early endosome membrane.
组织表达： Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
科研货号： PLA013000
SARA rabbit pAb
Catalog NoPLA013000
Product information
基因名称： ZFYVE9 MADHIP SARA SMADIP
蛋白名称： Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)
功能： Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Early endosome membrane.
组织表达： Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
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