功能： Catalyzes the transfer of phosphatidylinositol (PI) between membranes . Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC . Regulates RHOA activity, and plays a role in cytoskeleton remodeling . Necessary for normal completion of cytokinesis . Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus . Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus . Required for protein export from the endoplasmic reticulum and the Golgi . Binds calcium ions .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein. Endoplasmic reticulum membrane ; Peripheral membrane protein. Lipid droplet . Cleavage furrow . Midbody . Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets (PubMed:12225667). Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835). .
组织表达： Ubiquitous.
科研货号： PLA012826
Nir2 rabbit pAb
Catalog NoPLA012826
Product information
基因名称： PITPNM1 DRES9 NIR2 PITPNM
蛋白名称： Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)
功能： Catalyzes the transfer of phosphatidylinositol (PI) between membranes . Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC . Regulates RHOA activity, and plays a role in cytoskeleton remodeling . Necessary for normal completion of cytokinesis . Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus . Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus . Required for protein export from the endoplasmic reticulum and the Golgi . Binds calcium ions .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein. Endoplasmic reticulum membrane ; Peripheral membrane protein. Lipid droplet . Cleavage furrow . Midbody . Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets (PubMed:12225667). Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835). .
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