功能： Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, myofibril, sarcomere . Cytoplasm . Cytoplasm, cytosol . Cell membrane, sarcolemma . Membrane, caveola . Cell membrane . In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner. .
科研货号： PLA012711
MURC rabbit pAb
Catalog NoPLA012711
Product information
基因名称： MURC
蛋白名称： Muscle-related coiled-coil protein (Muscle-restricted coiled-coil protein)
功能： Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, myofibril, sarcomere . Cytoplasm . Cytoplasm, cytosol . Cell membrane, sarcolemma . Membrane, caveola . Cell membrane . In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner. .
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