功能： Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) . Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place . Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
科研货号： PLA012707
KMT2C rabbit pAb
Catalog NoPLA012707
Product information
基因名称： MLL3 HALR KIAA1506 KMT2C
蛋白名称： Histone-lysine N-methyltransferase MLL3 (EC 2.1.1.43) (Homologous to ALR protein) (Lysine N-methyltransferase 2C) (KMT2C) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
功能： Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) . Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place . Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
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