功能： Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Chromosome.
组织表达： Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
科研货号： PLA012674
FBXO11 rabbit pAb
Catalog NoPLA012674
Product information
基因名称： FBXO11 FBX11 VIT1 UG063H01
蛋白名称： F-box only protein 11 (Vitiligo-associated protein 1) (VIT-1)
功能： Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Chromosome.
组织表达： Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
在线咨询
湘公网安备