功能： Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 . Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity . Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Cell junction, adherens junction . Cytoplasm . Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction. .
组织表达： Predominantly expressed in erythroblasts.
科研货号： PLA012652
TSPAN33 rabbit pAb
Catalog NoPLA012652
Product information
基因名称： TSPAN33 PEN
蛋白名称： Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)
功能： Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 . Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity . Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Cell junction, adherens junction . Cytoplasm . Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction. .
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