功能： Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP . Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions . When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation . Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . The DRG1-ZC3H15/DFRP1 complex associates with polysomes.
组织表达： High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.
科研货号： PLA012611
DRG1 rabbit pAb
Catalog NoPLA012611
Product information
基因名称： DRG1 NEDD3
蛋白名称： Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3)
功能： Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP . Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions . When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation . Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . The DRG1-ZC3H15/DFRP1 complex associates with polysomes.
组织表达： High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.
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