功能： Catalytic subunit of protein phosphatase 6 (PP6) . PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation . N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 . During mitosis, regulates spindle positioning . Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 . Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation . Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 . CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion . Cytoplasm .
组织表达： Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.
功能： Catalytic subunit of protein phosphatase 6 (PP6) . PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation . N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 . During mitosis, regulates spindle positioning . Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 . Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation . Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 . CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion . Cytoplasm .
组织表达： Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.
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