蛋白名称： ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
功能： Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif . Mediates export of the GPCR receptor ADRA2B to the cell surface . Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein .
组织表达： Ubiquitously expressed.
科研货号： PLA012395
GGA2 rabbit pAb
Catalog NoPLA012395
Product information
基因名称： GGA2 KIAA1080
蛋白名称： ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
功能： Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif . Mediates export of the GPCR receptor ADRA2B to the cell surface . Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein .
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