功能： Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing . Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 . Required for splicing repression in M-phase cells and after heat shock . Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing . Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus speckle . Cytoplasm .
组织表达： Widely expressed.
科研货号： PLA012394
FUSIP1 rabbit pAb
Catalog NoPLA012394
Product information
基因名称： SRSF10 FUSIP1 FUSIP2 SFRS13A TASR
蛋白名称： Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
功能： Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing . Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 . Required for splicing repression in M-phase cells and after heat shock . Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing . Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator .
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