功能： Modulates negatively AKT-mediated GSK3B signaling . Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions . Plays a role in the regulation of cell cycle and cell adhesion . Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm .
组织表达： Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
科研货号： PLA012386
HN1 rabbit pAb
Catalog NoPLA012386
Product information
基因名称： HN1 ARM2
蛋白名称： Hematological and neurological expressed 1 protein (Androgen-regulated protein 2)
功能： Modulates negatively AKT-mediated GSK3B signaling . Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions . Plays a role in the regulation of cell cycle and cell adhesion . Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm .
组织表达： Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
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