蛋白名称： Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2)
功能： Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes . Can repress the expression of MMP7 in a ZBTB33-dependent manner . Can repress transactivation mediated by TCF12 . Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Colocalizes with ATN1 in discrete nuclear dots.
组织表达： Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
科研货号： PLA012372
RUNX1T1 rabbit pAb
Catalog NoPLA012372
Product information
基因名称： RUNX1T1 AML1T1 CBFA2T1 CDR ETO MTG8 ZMYND2
蛋白名称： Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2)
功能： Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes . Can repress the expression of MMP7 in a ZBTB33-dependent manner . Can repress transactivation mediated by TCF12 . Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Colocalizes with ATN1 in discrete nuclear dots.
组织表达： Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
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