功能： Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus, nucleolus . Recruited to the nucleolus by SAP30L.
组织表达： Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions.
功能： Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus, nucleolus . Recruited to the nucleolus by SAP30L.
组织表达： Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions.
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