功能： [Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate . Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis . Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan . ; [Isoform 3]: Lacks both N-deacetylase and N-sulfotransferase activities. Acts as a dominant negative on isoform 1, likely by changing the composition of enzyme complexes responsible for elongation and modification of heparan sulfates.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein . Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein .; [Isoform 3]: Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein .
组织表达： Widely expressed. Expression is most abundant in heart, liver and pancreas.
功能： [Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate . Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis . Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan . ; [Isoform 3]: Lacks both N-deacetylase and N-sulfotransferase activities. Acts as a dominant negative on isoform 1, likely by changing the composition of enzyme complexes responsible for elongation and modification of heparan sulfates.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein . Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein .; [Isoform 3]: Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein .
组织表达： Widely expressed. Expression is most abundant in heart, liver and pancreas.
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