功能： E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response . Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 . Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B . Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus . Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B. .
组织表达： Widely expressed.
科研货号： PLA012337
TRIM8 rabbit pAb
Catalog NoPLA012337
Product information
基因名称： TRIM8 GERP RNF27
蛋白名称： Probable E3 ubiquitin-protein ligase TRIM8 (EC 6.3.2.-) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (Tripartite motif-containing protein 8)
功能： E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response . Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 . Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B . Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus . Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B. .
在线咨询
湘公网安备