功能： Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing . Has an ATP-independent activity . Specifically cleaves peptides in the range of 5 to 65 residues . Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference . Degrades the transit peptides of mitochondrial proteins after their cleavage . Also degrades other unstructured peptides . It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion . It is a highly efficient protease, at least toward amyloid-beta protein 40 . Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently . It is also able to degrade amyloid-beta protein 42 .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion . Mitochondrion matrix .
组织表达： Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.
功能： Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing . Has an ATP-independent activity . Specifically cleaves peptides in the range of 5 to 65 residues . Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference . Degrades the transit peptides of mitochondrial proteins after their cleavage . Also degrades other unstructured peptides . It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion . It is a highly efficient protease, at least toward amyloid-beta protein 40 . Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently . It is also able to degrade amyloid-beta protein 42 .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion . Mitochondrion matrix .
组织表达： Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.
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