蛋白名称： A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95)
功能： Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export . Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA . May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 . May be involved in regulation of pre-mRNA splicing . ; (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. ; (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. ; (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus matrix . Nucleus speckle . Nucleus, PML body . Cytoplasm . Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). .
组织表达： Ubiquitously expressed. Expressed in the brain cortex (at protein level).
科研货号： PLA012262
AKAP8L rabbit pAb
Catalog NoPLA012262
Product information
基因名称： AKAP8L NAKAP NAKAP95 HRIHFB2018
蛋白名称： A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95)
功能： Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export . Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA . May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 . May be involved in regulation of pre-mRNA splicing . ; (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. ; (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. ; (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Nucleus matrix . Nucleus speckle . Nucleus, PML body . Cytoplasm . Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). .
组织表达： Ubiquitously expressed. Expressed in the brain cortex (at protein level).
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