功能： Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) . Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate . Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules . Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 . May play a role in the regulation of cellular cholesterol metabolism .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
组织表达： Ubiquitous.
科研货号： PLA012052
TMEM55B rabbit pAb
Catalog NoPLA012052
Product information
基因名称： TMEM55B C14orf9
蛋白名称： Transmembrane protein 55B (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase)
功能： Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) . Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate . Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules . Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 . May play a role in the regulation of cellular cholesterol metabolism .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
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