功能： DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase . Functions as ATP-dependent DNA translocase . Can promote Holliday junction branch migration (in vitro) .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Chromosome, centromere . Chromosome, centromere, kinetochore . Chromosome . Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. .
科研货号： PLA012039
ERCC6L rabbit pAb
Catalog NoPLA012039
Product information
基因名称： ERCC6L PICH
蛋白名称： DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)
功能： DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase . Functions as ATP-dependent DNA translocase . Can promote Holliday junction branch migration (in vitro) .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Chromosome, centromere . Chromosome, centromere, kinetochore . Chromosome . Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. .
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