功能： Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance . As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus . The Nup107-160 complex seems to be required for spindle assembly during mitosis . NUP85 is required for membrane clustering of CCL2-activated CCR2 . Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade . Involved in nephrogenesis .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasm . Nucleus membrane . During mitosis, localizes to the kinetochores and spindle poles (PubMed:12718872, PubMed:16807356). Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (PubMed:15995708). .
功能： Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance . As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus . The Nup107-160 complex seems to be required for spindle assembly during mitosis . NUP85 is required for membrane clustering of CCL2-activated CCR2 . Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade . Involved in nephrogenesis .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasm . Nucleus membrane . During mitosis, localizes to the kinetochores and spindle poles (PubMed:12718872, PubMed:16807356). Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (PubMed:15995708). .
在线咨询
湘公网安备