功能： Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation . Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane. Cell projection, lamellipodium. Nucleus . Cytoplasm . Colocalizes with actin at the leading edge of polarized cells.
组织表达： Expressed in a variety of tissues.
科研货号： PLA011989
MCC rabbit pAb
Catalog NoPLA011989
Product information
基因名称： MCC
蛋白名称： Colorectal mutant cancer protein (Protein MCC)
功能： Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation . Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane. Cell projection, lamellipodium. Nucleus . Cytoplasm . Colocalizes with actin at the leading edge of polarized cells.
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