功能： E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Its function in the WMM complex is unknown .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus speckle . Nucleus, nucleoplasm . Cytoplasm . Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. .
科研货号： PLA011899
CBLL1 rabbit pAb
Catalog NoPLA011899
Product information
基因名称： CBLL1 HAKAI RNF188
蛋白名称： E3 ubiquitin-protein ligase Hakai (EC 6.3.2.-) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (RING finger protein 188) (c-Cbl-like protein 1)
功能： E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Its function in the WMM complex is unknown .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus speckle . Nucleus, nucleoplasm . Cytoplasm . Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. .
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