功能： RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA . Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex . Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist . Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation . Inhibits pre-mRNA splicing . Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleoplasm . Nucleus speckle . Nucleus envelope . Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli. .
组织表达： Ubiquitously expressed.
科研货号： PLA011866
RBM15B rabbit pAb
Catalog NoPLA011866
Product information
基因名称： RBM15B OTT3
蛋白名称： Putative RNA-binding protein 15B (One-twenty two protein 3) (HuOTT3) (RNA-binding motif protein 15B)
功能： RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA . Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex . Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist . Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation . Inhibits pre-mRNA splicing . Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 .
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleoplasm . Nucleus speckle . Nucleus envelope . Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli. .
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